- Jim Shooter (1978–1987)
- Tom DeFalco (1987–1994)
- No overall; separate group editors-in-chief (1994–1995)
- Mark Gruenwald, Universe (Avengers & Cosmic)
- Bob Harras, Mutant
- Bob Budiansky, Spider-Man
- Bobbie Chase, Marvel Edge
- Carl Potts, Epic Comics & general entertainment
- Bob Harras (1995–2000)
- Joe Quesada (2000–2011)
- Axel Alonso (2011–present)